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1

Effects of Phyllanthus plant extracts on duck hepatitis B virus in vitro and in vivo

Andrew Shead, Karen Vickery, Aniko Pajkos, Robert Medhurst, John Freiman, Robert Dixon, Yvonne Cossart

Journal:

Antiviral Research

Year:

1992

Language:

english

File:

PDF, 664 KB

english, 1992

2

Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin

Andrew D. Medhurst, Carol A. Jennings, Melanie J. Robbins, Robert P. Davis, Catherine Ellis, Kim Y. Winborn, Kenneth W. M. Lawrie, Guillaume Hervieu, Graham Riley, Jane E. Bolaky, Nicole C. Herrity, P

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 207 KB

english, 2003

3

Symposium: Interdisciplinary Perspectives on Rhetorical Criticism

Enos, Richard Leo, Campbell, Karlyn Kohrs, King, Andrew, Condit, Celeste M., Jensen, Richard J., Foss, Sonja K., Medhurst, Martin J., Zarefsky, David

Journal:

Rhetoric Review

Year:

2006

Language:

english

File:

PDF, 210 KB

english, 2006

4

Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists

Giancarlo Trani, Stuart M. Baddeley, Michael A. Briggs, Tsu T. Chuang, Nigel J. Deeks, Christopher N. Johnson, Abir A. Khazragi, Tania L. Mead, Andrew D. Medhurst, Peter H. Milner, Leann P. Quinn, Ali

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 160 KB

english, 2008

5

Structure–activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

Paul J. Beswick, Andy Billinton, Laura J. Chambers, David K. Dean, Elena Fonfria, Robert J. Gleave, Stephen J. Medhurst, Anton D. Michel, Andrew P. Moses, Sadhana Patel, Shilina A. Roman, Sue Roomans,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 381 KB

english, 2010

6

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor

Lee Abberley, Aude Bebius, Paul J. Beswick, Andy Billinton, Katharine L. Collis, David K. Dean, Elena Fonfria, Robert J. Gleave, Stephen J. Medhurst, Anton D. Michel, Andrew P. Moses, Sadhana Patel, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

7

The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models

Andrew D Medhurst, David C Harrison, Simon J Read, Colin A Campbell, Melanie J Robbins, Menelas N Pangalos

Journal:

Journal of Neuroscience Methods

Year:

2000

Language:

english

File:

PDF, 718 KB

english, 2000

8

Simultaneous measurement of [3H]noradrenaline release and neurogenic contraction under identical conditions, to determine the prejunctional inhibitory effects of SKF 99101H and BRL 56905 in dog saphenous vein

A. D. Medhurst, Antony M. Brown, Alberto J. Kaumann, Andrew A. Parsons

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1997

Language:

english

File:

PDF, 196 KB

english, 1997

9

Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat

Patrizia Giannoni, Maria-Beatrice Passani, Daniele Nosi, Paul L. Chazot, Fiona C. Shenton, Andrew D. Medhurst, Leonardo Munari, Patrizio Blandina

Journal:

European Journal of Neuroscience

Year:

2009

Language:

english

File:

PDF, 917 KB

english, 2009

10

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

Lilia Marinova-Mutafchieva, Mona Sadeghian, Lauren Broom, John B. Davis, Andrew D. Medhurst, David T. Dexter

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 620 KB

english, 2009

11

Characterization of NK3 receptors in rabbit isolated iris sphincter muscle

Andrew D Medhurst, Andrew A Parsons, Jennifer C Roberts, Douglas W P Hay

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 608 KB

english, 1997

12

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists

Andrew D. Medhurst, Douglas W. P. Hay, Andrew A. Parsons, Lenox D. Martin, Don E. Griswold

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 370 KB

english, 1997

13

Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle

Andrew D Medhurst, Warren D Hirst, Jeffery C Jerman, Jacqueline Meakin, Jennifer C Roberts, Tania Testa, Darren Smart

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 550 KB

english, 1999

14

Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist

Jim J Hagan, Gary W Price, Phillip Jeffrey, Nigel J Deeks, Tania Stean, David Piper, Martin I Smith, Neil Upton, Andrew D Medhurst, Derek N Middlemiss, Graham J Riley, Peter J Lovell, Steven M Bromidg

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 209 KB

english, 2000

15

Effects of 6-hydroxydopamine on pre- and post-junctional 5-HT1-like receptor-mediated responses in dog saphenous vein

Andrew D. Medhurst, Gerd E. K. Novotny, Stephen G. Parker, Nicola M. Deighton, Alberto J. Kaumann

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1993

Language:

english

File:

PDF, 2.43 MB

english, 1993

16

Cross-tolerance between muscarinic agonists: Role of muscarinic receptors

Allan C. Collins, Toni N. Smolen, Andrew Smolen, Laura J. Medhurst

Journal:

Pharmacology Biochemistry and Behavior

Year:

1987

Language:

english

File:

PDF, 963 KB

english, 1987

17

The GABAB2 subunit is critical for the trafficking and function of native GABAB receptors

Seb J. Thuault, Jon T. Brown, Steven A. Sheardown, Sabine Jourdain, Benjamin Fairfax, Jonathan P. Spencer, Sophie Restituito, Josephine H.L. Nation, Stephanie Topps, Andrew D. Medhurst, Andrew D. Rand

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 417 KB

english, 2004

18

Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats

Andrew D. Medhurst, Michael A. Briggs, Gordon Bruton, Andrew R. Calver, Iain Chessell, Barry Crook, John B. Davis, Robert P. Davis, Andrew G. Foley, Teresa Heslop, Warren D. Hirst, Stephen J. Medhurst

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 578 KB

english, 2007

19

Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP

Jose A. Aguirre, Jan Kehr, Takashi Yoshitake, Fang-Ling Liu, Alicia Rivera, Sergio Fernandez-Espinola, Beth Andbjer, Giuseppina Leo, Andrew D. Medhurst, Luigi F. Agnati, Kjell Fuxe

Journal:

Year:

2005

Language:

english

File:

PDF, 422 KB

english, 2005

20

Identification of a novel 5-HT4 receptor splice variant (r5-HT4c1) and preliminary characterisation of specific 5-HT4a and 5-HT4b receptor antibodies

Alison M. Ray, Rosemary E. Kelsell, Jennifer A. Houp, Fiona M. Kelly, Andrew D. Medhurst, Helen M. Cox, Andrew R. Calver

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 959 KB

english, 2009

21

Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease

Lauren Broom, Lilia Marinova-Mutafchieva, Mona Sadeghian, John B. Davis, Andrew D. Medhurst, David T. Dexter

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1003 KB

english, 2011

22

Cloning and Characterization of Human NTT5 and v7-3: Two Orphan Transporters of the Na+/Cl−-Dependent Neurotransmitter Transporter Gene Family

Maurice K. Farmer, Melanie J. Robbins, Andrew D. Medhurst, David A. Campbell, Kathryn Ellington, Malcolm Duckworth, Anthony M. Brown, Derek N. Middlemiss, Gary W. Price, Menelas N. Pangalos

Journal:

Year:

2000

Language:

english

File:

PDF, 571 KB

english, 2000

23

Nitric oxide synthase inhibitors 7- and 6-nitroindazole relax smooth muscle in vitro

Andrew D. Medhurst, Carol Greenlees, Andrew A. Parsons, Susan J. Smith

Journal:

European Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 170 KB

english, 1994

24

Autoradiographical imaging of PPARγ agonist effects on PBR/TSPO binding in TASTPM mice

Jennifer C. Roberts, Sarah L. Friel, Shilina Roman, Marion Perren, Alex Harper, John B. Davis, Jill C. Richardson, David Virley, Andrew D. Medhurst

Journal:

Experimental Neurology

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

25

Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain

Stephen J. Medhurst, Sue D. Collins, Andy Billinton, Sharon Bingham, Robert G. Dalziel, Amanda Brass, Jennifer C. Roberts, Andrew D. Medhurst, Iain P. Chessell

Journal:

Year:

2008

Language:

english

File:

PDF, 402 KB

english, 2008

26

Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery

Andrew D. Medhurst, Gillian Rennie, Conrad G. Chapman, Helen Meadows, Malcolm D. Duckworth, Rosemary E. Kelsell, Israel I. Gloger, Menelas N. Pangalos

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 2.85 MB

english, 2001

27

Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR

Andrew D. Medhurst, Frank Lezoualc’h, Rodolphe Fischmeister, Derek N. Middlemiss, Gareth J. Sanger,

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 878 KB

english, 2001

28

mRNA distribution analysis of human TRPC family in CNS and peripheral tissues

Antonio Riccio, Andrew D Medhurst, Cesar Mattei, Rosemary E Kelsell, Andrew R Calver, Andrew D Randall, Christopher D Benham, Menelas N Pangalos

Journal:

Molecular Brain Research

Year:

2002

Language:

english

File:

PDF, 1.09 MB

english, 2002

29

The use of quantitative RT-PCR to measure mRNA expression in a rat model of focal ischemia — caspase-3 as a case study

David C Harrison, Andrew D Medhurst, Brian C Bond, Colin A Campbell, Robert P Davis, Karen L Philpott

Journal:

Molecular Brain Research

Year:

2000

Language:

english

File:

PDF, 305 KB

english, 2000

30

P1-402 Pre-clinical evaluation of novel H3 receptor antagonists

Andrew R. Calver, David M. Wilson, Andrew D. Medhurst

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 167 KB

english, 2004

31

Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium

Andrew D. Medhurst, Alberto J. Kaumann

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.47 MB

english, 1993

32

Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 2. Identification of ( S )- N -(1-Phenylpropyl)-3-hydroxy-2- phenylquinoline-4-carboxamide (SB 223412) †

Giardina, Giuseppe A. M., Raveglia, Luca F., Grugni, Mario, Sarau, Henry M., Farina, Carlo, Medhurst, Andrew D., Graziani, Davide, Schmidt, Dulcie B., Rigolio, Roberto, Luttmann, Mark, Cavagnera, Stef

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 268 KB

english, 1999

33

O3-05-01: GSK189254 - a novel H3 receptor antagonist that binds to H3 receptors in the human brain and improves cognitive performance in preclinical models

Andrew D. Medhurst, Barry Crook, Sandrine Ociepka, Robert P. Davies, Andrew Calver, Alison Ray, Tania Stean, Brenda Trail, Graham Wadsworth, Kim Brackenborough, Rebecca K. Davis, M. Isabel Gonzalez, D

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 67 KB

english, 2006

34

Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias

Yuan Sheng, Jasinda H. Lee, Andrew D. Medhurst, Gordon K. Wilcock, Margaret Esiri, Peter T.-H. Wong, Christopher P. Chen, Mitchell K.P. Lai

Journal:

Journal of the Neurological Sciences

Year:

2012

Language:

english

File:

PDF, 295 KB

english, 2012

35

Dynamics of Aβ42 Reduction in Plasma, CSF and Brain of Rats Treated with the γ-Secretase Modulator, GSM-10h

Hawkins, Julie, Harrison, David C., Ahmed, Sharlin, Davis, Robert P., Chapman, Trevor, Marshall, Ian, Smith, Beverley, Mead, Tania L., Medhurst, Andrew, Giblin, Ged M.P., Hall, Adrian, Gonzalez, Maria

Journal:

Neurodegenerative Diseases

Year:

2011

Language:

english

File:

PDF, 519 KB

english, 2011

36

Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 1. Identification of the 4-Quinolinecarboxamide Framework

Giardina, Giuseppe A. M., Sarau, Henry M., Farina, Carlo, Medhurst, Andrew D., Grugni, Mario, Raveglia, Luca F., Schmidt, Dulcie B., Rigolio, Roberto, Luttmann, Mark, Vecchietti, Vittorio, Hay, Dougla

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 408 KB

english, 1997

37

(.+-.)-3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analog of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor

King, Frank D., Brown, Anthony M., Gaster, Laramie M., Kaumann, Alberto J., Medhurst, Andrew D., Parker, Stephen G., Parsons, Andrew A., Patch, Tracey L., Raval, Pravin

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 208 KB

english, 1993

38

P4-387

Chuang, Aaron T.T., Foley, Andrew, Pugh, Perdita L., Sunter, David, Tong, Xin, Regan, Ciaran, Dawson, Lee A., Medhurst, Andrew D., Upton, Neil

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 66 KB

english, 2006

39

Histaminergic H3 receptors in subcortical ischemic vascular dementia

Sheng, Yuan, Lee, Jasinda, Medhurst, Andrew, Wilcock, Gordon, Wong, Peter, Lai, Mitchell K.P., Chen, Christopher

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 55 KB

english, 2011

40

P4-327: Effects of the novel 5-HT6 SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition

Ray, Alison M., Hirst, Warren D., Ahmed, Mahmood, Johnson, Christopher N., Witty, David R., Sunter, David, Quinn, Leann P., Stean, Tania O., Trail, Brenda K., Foley, Andrew, Upton, Neil, Medhurst, And

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 55 KB

english, 2008

41

THE CONSULTANT'S JOB

Medhurst, G.A., Andrews, P.S.

Journal:

Year:

1969

Language:

english

File:

PDF, 317 KB

english, 1969

42

(.+-.)-3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: A conformationally restricted analog of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor. [Erratum to document cited in CA119(11):117079z]

King, Frank D., Brown, Anthony M., Gaster, Laramie M., Kaumann, Alberto J., Medhurst, Andrew D., Parker, Stephen G., Parsons, Andrew A., Patch, Tracey L., Raval, Pravin

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 48 KB

english, 1993

43

2-Phenyl-4-quinolinecarboxamides: A Novel Class of Potent and Selective Non-Peptide Competitive Antagonists for the Human Neurokinin-3 Receptor

Giardina, Giuseppe A. M., Sarau, Henry M., Farina, Carlo, Medhurst, Andrew D., Grugni, Mario, Foley, James J., Raveglia, Luca F., Schmidt, Dulcie B., Rigolio, Roberto, Vassallo, Marco, Vecchietti, Vit

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 138 KB

english, 1996

44

H3 Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and Improves Memory Consolidation in Odor Discrimination and Delayed Match-to-Position Paradigms

Foley, Andrew G, Prendergast, Alison, Barry, Claire, Scully, Darren, Upton, Neil, Medhurst, Andrew D, Regan, Ciaran M

Journal:

Neuropsychopharmacology

Year:

2009

Language:

english

File:

PDF, 697 KB

english, 2009

45

Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca 2+ Influx

Riccio, Antonio, Mattei, Cesar, Kelsell, Rosemary E., Medhurst, Andrew D., Calver, Andrew R., Randall, Andrew D., Davis, John B., Benham, Christopher D., Pangalos, Menelas N.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 325 KB

english, 2002

46

The novel cyclooxygenase-2 inhibitor GW637185X protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

Aguirre, Jose A., Leo, Giuseppina, Cueto, Raquel, Andbjer, Beth, Naylor, Alan, Medhurst, Andrew D., Agnati, Luigi F., Fuxe, Kjell

Journal:

Year:

2008

Language:

english

File:

PDF, 268 KB

english, 2008

47

The Consultant's Job

Medhurst, G. A., Andrews, P. S.

Journal:

Year:

1969

Language:

english

File:

PDF, 197 KB

english, 1969

48

Hospital staffing structure.

Medhurst, G, Andrews, P

Journal:

Year:

1970

Language:

english

File:

PDF, 304 KB

english, 1970

49

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond — Part 2

Shore, Daniel G.M., Sweeney, Zachary K., Beresford, Alan, Chan, Bryan K., Chen, Huifen, Drummond, Jason, Gill, Andrew, Kleinheinz, Tracy, Liu, Xingrong, Medhurst, Andrew D., McIver, Edward G., Moffat,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 844 KB

english, 2018

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